Resources

Selected Publications

Serum Glial Fibrillary Acidic Protein and Neurofilament Light Chain Levels Reflect Different Mechanisms of Disease Progression under B-Cell Depleting Treatment in Multiple Sclerosis

Benkert et al., Annals of Neurology, 2024

MultiSCRIPT-Cycle 1-a pragmatic trial embedded within the Swiss Multiple Sclerosis Cohort (SMSC) on neurofilament light chain monitoring to inform personalized treatment decisions in multiple sclerosis: a study protocol for a randomized clinical trial

Janiaud et al., Trials, 2024

Complement Activation Is Associated With Disease Severity in Multiple Sclerosis

Oechtering et al., Neurol Neuroimmunol Neuroinflamm, 2024

Association of Spinal Cord Atrophy and Brain Paramagnetic Rim Lesions With Progression Independent of Relapse Activity in People With MS

Cagol et al., Neurology, 2024

Neurofilament Light Chain Elevation and Disability Progression in Multiple Sclerosis

Abdelhak et al., JAMA Neurology, 2024

A Multicenter Longitudinal MRI Study Assessing LeMan-PV Software Accuracy in the Detection of White Matter Lesions in Multiple Sclerosis Patients

Todea et al., J Magn Reson Imaging, 2023

Serum neurofilament light chain reference database for individual application in paediatric care: a retrospective modelling and validation study

Abdelhak et al., Lancet Neurology, 2023

Serum Glial Fibrillary Acidic Protein Compared With Neurofilament Light Chain as a Biomarker for Disease Progression in Multiple Sclerosis

Meier et al., Jama Neurol, 2023

Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study

Todea et al., J Magn Reson Imaging, 2023

Association of Brain Atrophy With Disease Progression Independent of Relapse Activity in Patients With Relapsing Multiple Sclerosis

Cagol et al., Jama Neurol, 2022

Intrathecal IgM Synthesis Is Associated with Spinal Cord Manifestation and Neuronal Injury in Early MS

Oechtering et al., Annals of Neurology, 2022

Intrathecal Immunoglobulin M Synthesis is an Independent Biomarker for Higher Disease Activity and Severity in Multiple Sclerosis

Oechtering et al., Annals of Neurology, 2021

Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis

Disanto et al., Annals of Neurology, 2017

The Swiss Multiple Sclerosis Cohort-Study (SMSC): A Prospective Swiss Wide Investigation of Key Phases in Disease Evolution and New Treatment Options

Disanto et al., Plos One, 2016

Applications

Serum Neurofilament Light Chain Reference App

Serum neurofilament light chain reference app (pediatric)

SMSC variable list (metadata):

With the support of the Swiss Personalized Health Network (SPHN), the entire list of variables collected in the SMSC is made publicly on the internationally renowned metadata catalogue Maelstrom, thereby increasing findability and usability of the data:
https://www.maelstrom-research.org/study/smsc

SMSC - Swiss MS Cohort

Multiple Sklerose Zentrum und Neuroimmunologie

Universitätsspital Basel

Spitalstrasse 2, CH-4031 Basel, Switzerland

jens.kuhle@usb.ch

Universitätsspital Basel Kantonsspital St. Gallen
Kantonsspital Aarau
Inselspital - Universitätsspital Bern Universitätsspital Zürich Hôpitaux Universitaires Genève
Centres hospitalier universitaire vaudois
Ospedale Regionale di Lugano
Kantonsspital Luzern

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